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1.
Nurs Inq ; 31(2): e12615, 2024 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-38013628

RESUMO

Nurses have moral obligations incurred by membership in the profession to participate knowingly in health policy advocacy. Many barriers have historically hindered nurses from realizing their potential to advance health policy. The contemporary political context sets additional challenges to policy work due to polarization and conflict. Nursing education can help nurses recognize their role in advancing health through political advocacy in a manner that is consistent with disciplinary knowledge and ethical responsibilities. In this paper, the authors describe an exemplar of Elizabeth Barrett's "Power as Knowing Participation in Change" theory as a disciplinary lens within a doctoral nursing health policy course. Barrett (radically) emphasizes "power as freedom" instead of "power as control." This approach is congruent with nursing disciplinary values and enhances awareness of personal freedom and building collaborative relationships in the policy process. The theory was used in concert with other traditional policy content and frameworks from nursing and other disciplines. We discuss the role of nursing ethics viewed as professional responsibility for policy action, an overview of Barrett's theory, and the design of the course. Four student reflections on how the course influenced their thinking about policy advocacy are included. While not specific to policymaking, Barrett's theory provides a disciplinary grounding to increase students' awareness of freedom and choices in political advocacy participation. Our experience suggests that Barrett's work can be fruitful for enhancing nurses' awareness of choices to participate in change across settings.

2.
Child Care Health Dev ; 50(1): e13206, 2024 01.
Artigo em Inglês | MEDLINE | ID: mdl-38123168

RESUMO

BACKGROUND: Children with medical complexity (CMC) account for 1% of children in the United States. These children experience frequent hospital readmissions, high healthcare costs and poor health outcomes. A link between CMC caregiver social support, resilience and hospital readmissions has never been fully investigated. This study examines the feasibility of a prospective, descriptive, repeated measures research design to characterize CMC and their caregivers, social supports, caregiver resilience and hospital readmissions to inform a larger prospective investigation. METHODS: Caregivers of CMC with unplanned hospitalizations completed surveys at the index hospitalization and 30 and 60 days after discharge. CMC caregiver and child characteristics, social supports and hospital readmissions were examined using an investigator-developed survey. Resilience was measured using the Resilience Scale-14© (7-Point Likert Scale, score range 14-98), and feasibility was measured by calculating enrolment, attrition, survey completion and item response. Analysis included descriptive statistics and qualitative data visualization. RESULTS: Of caregivers who were approached for participation, 81.1% consented  and completed 76 surveys. Attrition was 31%. Item response rates were ≥ 90% for all but one item. A total of 62.1% of children had hospital readmissions within 90 days and 37.9% within 30 days. Additionally, 70% of caregivers had home care nursing, but the approved hours were only partially filled. More than 70% of caregiver resilience scores were moderate to high (score range 74-98) and were stable across repeated measures and hospital readmissions. Open-ended question responses revealed the following five categories: All-consuming, Family Reliance, Impact of Covid, Taking Action and Broken System. CONCLUSIONS: Studying CMC caregiver social supports and resilience using repeated measures is feasible. CMC caregivers reported stressors including coordinating their child's substantial healthcare needs and managing partially filled home care nursing hours. Caregiver resilience remained stable over time, amidst frequent CMC hospital readmissions. Findings can inform future research priorities and power analyses for CMC caregiver resilience.


Assuntos
Cuidadores , Testes Psicológicos , Resiliência Psicológica , Criança , Humanos , Readmissão do Paciente , Estudos Prospectivos , Apoio Social
3.
Subst Abuse Treat Prev Policy ; 18(1): 71, 2023 11 27.
Artigo em Inglês | MEDLINE | ID: mdl-38012728

RESUMO

BACKGROUND: As a subfield of prevention science, substance use prevention researchers and professionals are increasingly focused on translating research into practice, developing the workforce of prevention specialists, and creating a robust prevention infrastructure. One critical need for professional development among the substance use prevention workforce is training and technical assistance around how to include young people in developing, implementing, and evaluating substance use prevention programs. MAIN BODY: Amplifying youth voices can increase the quality and responsiveness of youth prevention research and practice, as well as hasten and improve the translation of prevention interventions into practice while also benefiting youth themselves. Yet, youth engagement is multi-layered and nuanced. Training prevention professionals who work with youth in youth development and youth/adult partnerships is critical to support meaningful youth engagement efforts. We assert that the substance use prevention workforce needs at least three specific competencies to engage youth meaningfully in prevention: 1) understand adolescent development and the core elements of youth-adult partnerships; 2) apply this knowledge to program design and practice; and 3) implement relational practices to share power with young people. CONCLUSION: Incorporating the insights of young people can improve substance use prevention. The substance use prevention workforce should be supported in developing competencies to meaningfully engage youth. These competencies require training, and resources must be devoted to support appropriate training.


Assuntos
Transtornos Relacionados ao Uso de Substâncias , Adolescente , Humanos , Transtornos Relacionados ao Uso de Substâncias/prevenção & controle
4.
Health Promot Pract ; 24(4): 606-608, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-36571387

RESUMO

LGBTQIA+ (lesbian, gay, bisexual, transgender, queer or questioning, intersex, asexual, and more) youth in rural communities have little to no access to gender or sexuality-affirming support, compared with their peers in the metro areas of Colorado. Without access to support and exposure to bullying or discrimination, many rural LGBTQIA+ youth struggle to find belonging. Staff from One Colorado and the Hub for Justice-centered Youth Engagement partnered to develop Colorado's Queer Youth Network (CQYN) to foster a virtual community to support rural LGBTQIA+ youth, enhance belonging and acceptance, and feel empowered to make a change in their community. CQYN is offered virtually, every other week during the academic year, to create a consistent safe space for rural LGBTQIA+ youth and to offer opportunities to grow their unique leadership skills and connect with affirming LGBTQIA+ adults. This article highlights the development of the partnership, design of the virtual network, and challenges in recruiting youth who have been pushed to the margins.


Assuntos
Minorias Sexuais e de Gênero , Pessoas Transgênero , Adulto , Feminino , Humanos , Adolescente , População Rural , Colorado , Identidade de Gênero
5.
Health Promot Pract ; 24(6): 1151-1162, 2023 11.
Artigo em Inglês | MEDLINE | ID: mdl-36050932

RESUMO

Movements designed to engage youth in tobacco control have been an important part of tobacco prevention for decades. Today, young people are increasingly diverse, and their primary issues of concern are gun control, racism, mental health, and climate change. To engage today's young people, tobacco control programs need to draw connections between youth's identities, top issues, and tobacco. UpRISE is a social justice youth tobacco control movement that engages diverse youth in identifying the root causes of youth nicotine use. In 2018-2019, 21 youth-serving organizations and schools hosted youth coalitions. Coalitions engaged in a six-session workbook called "Getting to the root cause," and adults were provided training and reflective supervision. Pre/post surveys with youth participants (n = 180) and end-of-year interviews with adult facilitators (n = 22) were used to assess outcomes. The primary outcomes were supportive adult relationships, youth voice in decision-making, anti-tobacco industry attitudes and beliefs, psychological empowerment, critical consciousness, and global belief in a just world. Quantitative measures of supportive adult relationships, youth voice in decision-making, psychological empowerment, and anti-tobacco industry attitudes and beliefs all increased significantly over time (p < .0001, p < .0001, p < .0001, p = .0034, respectively). Critical consciousness and global belief in a just world did not change significantly. During interviews, adults reported learning how: to engage in youth-adult partnerships, the tobacco industry abused its power, to engage in critical reflection about power. Adults also felt empowered. UpRISE may be a promising approach to increase racially diverse youth's engagement in social justice-oriented tobacco control efforts that advance equity.


Assuntos
Empoderamento , Controle do Tabagismo , Adulto , Humanos , Adolescente , Nicotiana , Instituições Acadêmicas , Justiça Social
6.
Health Care Manage Rev ; 47(4): 350-359, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36036897

RESUMO

ISSUE: Prior to the COVID-19 pandemic, there was evidence of challenges surrounding the psychological well-being of health care professionals (HCPs). HCPs already frayed psychological ability to cope risks being further compromised by COVID-19-related stresses. CRITICAL THEORETICAL ANALYSIS: Most research on stress, psychological distress, and coping among HCPs is done in a piecemeal manner without a theoretical model connecting these different but related phenomena. This critical advancement article aims to apply and extend Wheaton and Montazer's model of stressors, stress, and distress to the literature on HCPs, generally, and COVID-19, specifically, to summarize past and guide future research on HCPs' mental health, resilience, and coping. Our model describes how different sources of support buffer the effect of stressors on stress and how coping strategies moderate the effect of stress on psychological distress. ADVANCE: We extended the model by (a) distinguishing context from the support in HCPs' environment; (b) distinguishing adaptive from maladaptive coping strategies and their relationships with antecedents and outcomes; (c) describing the adverse impacts that psychological distress has on patients, HCPs, and health services; and (d) describing how such outcomes can become stressors, in turn, further contributing to HCPs' stress in a vicious cycle. PRACTICE IMPLICATIONS: Our model provides a broader perspective of HCPs' work-related mental health and helps guide the creation, implementation, and evaluation of different sources of support and promote adaptive coping strategies. This model helps HCPs, researchers, and health services managers better understand and respond to the well-being crisis HCPs are facing, especially during the pandemic.


Assuntos
COVID-19 , Adaptação Psicológica , Pessoal de Saúde/psicologia , Humanos , Pandemias
7.
Br J Educ Psychol ; 92(4): 1458-1486, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-35538624

RESUMO

BACKGROUND: Math anxiety is a common experience that interferes with learning and achievement in mathematics. Considering that mathematics learning mostly takes place within the classroom, it is critical to examine how math anxiety develops in this context. AIMS: The purpose of the current scoping review was to identify classroom-learning environment factors associated with math anxiety in elementary and high school students. SAMPLE(S): Out of an initial sample of 3011 studies, 28 were eligible for inclusion. METHODS: Data on author(s), publication year, and study location; sample demographics; classroom variables; intervention details (if applicable); measures; and key results were extracted from articles. RESULTS: Numerous protective and vulnerability factors were identified. CONCLUSIONS: Directions for future research and methodological implications were explored.


Assuntos
Ansiedade , Estudantes , Humanos , Matemática , Logro , Aprendizagem
8.
Soc Work ; 67(3): 286-295, 2022 06 20.
Artigo em Inglês | MEDLINE | ID: mdl-35470395

RESUMO

The social work profession has made tremendous contributions to youth well-being, laying the foundation for social welfare systems and child protection laws. However, deficit-based constructions of youth are deeply engrained in the profession. Social work researchers have called for attention to critical approaches like youth participatory action research (YPAR). YPAR has an action-oriented epistemology and engages youth as coresearchers, providing an opportunity to shift social work research and practice paradigms. Yet, social work scholars lag behind cognate disciplines in adopting YPAR. This article examines challenges that have stymied YPAR in social work. The authors review the historical roots of the profession and its relationship to youth; examine present challenges, including social work's training and career progression; and make suggestions for the future, calling social work to affirm our values by reevaluating the way we do research on youth, the way we train future social workers, and the paradigms driving our practice.


Assuntos
Pesquisa Participativa Baseada na Comunidade , Serviço Social , Adolescente , Pesquisa sobre Serviços de Saúde , Humanos
9.
J Contin Educ Health Prof ; 42(1): e44-e52, 2022 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-33973927

RESUMO

INTRODUCTION: Health care providers (HCPs) have experienced more stress and burnout during COVID-19 than before. We compared sources and levels of stress, distress, and approaches to coping between nurses and physicians, and examined whether coping strategies helped mitigate the negative impact of stress and intentions to quit. METHODS: Using a cross-sectional study design, burnout was measured with the Maslach Burnout Inventory. Psychological distress was measured using the Depression, Anxiety, and Stress Scale. A self-reported survey was used to evaluate stressors, impact on perceived performance, and intentions to quit. The data were analyzed using t-tests and linear regression models. RESULTS: Responses of 119 HCPs were analyzed. Findings suggest that (1) compared to physicians, nurses experienced a higher level of distress and burnout, and used more maladaptive coping strategies. (2) Both nurses and physicians experienced more distress and burnout during COVID-19 than before. (3) Adaptive coping strategies moderated the negative impact of stress on work performance (4) Adaptive coping strategies moderated the negative effect of stress on burnout, which in turn reduced intentions to quit. Stress negatively impacted work performance and burnout only for those with low, but not high, levels of adaptive coping strategies. DISCUSSION: The current findings of HCPs' challenges, risks, and protective factors provide valuable information (1) on COVID-19's impact on HCPs, (2) to guide the distribution of institutional supportive efforts and recommend adaptive coping strategies, and (3) to inform medical education, such as resilience training, focusing on adaptive coping approaches.


Assuntos
Esgotamento Profissional , COVID-19 , Enfermeiras e Enfermeiros , Médicos , Adaptação Psicológica , Esgotamento Profissional/psicologia , Esgotamento Psicológico , COVID-19/epidemiologia , Estudos Transversais , Humanos , Intenção , Médicos/psicologia , SARS-CoV-2 , Estresse Psicológico , Inquéritos e Questionários
10.
Front Sports Act Living ; 3: 658293, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34056588

RESUMO

While there has been research into what teams, leagues, and athletes post on social media and the impact of post content on social media engagement, there is limited understanding and empirical research on the impact of broadcasting media on social sport consumption. There are an increasing number of new media through which sport leagues can distribute their content to fans. This research examines the impact of different broadcast platforms on game day engagement with WNBA team Twitter accounts. Using data for the 2016-2018 seasons, results indicate athlete/team quality and performance were positively associated with post engagement, underscoring the importance of the core sport product and potentially indicating that the WNBA is developing a star-driven culture similar to the NBA. In addition, broadcasting on League Pass or local TV (for home teams) and Twitter were associated with lower post engagement suggesting we have more to learn about maximizing online engagement.

11.
Eval Health Prof ; 44(3): 319-322, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33902348

RESUMO

Increased stressful experiences are pervasive among healthcare providers (HCPs) during the COVID-19 pandemic. Identifying resources that help mitigate stress is critical to maintaining HCPs' well-being. However, to our knowledge, no instrument has systematically examined how different levels of resources help HCPs cope with stress during COVID-19. This cross-sectional study involved 119 HCPs (64 nurses and 55 physicians) and evaluated the perceived availability, utilization, and helpfulness of a list of personal, hospital, and healthcare system resources. Participants also reported on their level of burnout, psychological distress, and intentions to quit. Results revealed that HCPs perceived the most useful personal resource to be family support; the most useful hospital resources were a safe environment, personal protective equipment, and support from colleagues; the most useful system resources were job protection, and clear communication and information about COVID. Moreover, HCPs who perceived having more available hospital resources also reported lower levels of psychological distress symptoms, burnout, and intentions to quit. Finally, although training and counseling services were perceived as useful to reduce stress, training was not perceived as widely available, and counseling services, though reported as being available, were underutilized. This instrument helps identify resources that support HCPs, providing implications for healthcare management.


Assuntos
COVID-19/epidemiologia , Pessoal de Saúde/psicologia , Serviços de Saúde do Trabalhador/organização & administração , Estresse Ocupacional/epidemiologia , Esgotamento Profissional/epidemiologia , Estudos Transversais , Meio Ambiente , Relações Familiares/psicologia , Feminino , Humanos , Masculino , Estresse Ocupacional/psicologia , Estresse Ocupacional/terapia , Pandemias , Quebeque , SARS-CoV-2 , Gestão da Segurança/organização & administração , Local de Trabalho/psicologia
12.
Front Psychol ; 11: 608522, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33679497

RESUMO

The mental health of young people is a growing public health concern. With socio-emotional difficulties in youth often resulting in psychiatric disorders later in life and most with mental health conditions rather stabilizing in time, it is essential to support healthy socio-emotional development. With a comprehensive definition of mental health, since emotion regulation (ER) plays a critical role in prevention, it becomes imperative to better understand how children effectively manage their emotions from an early age. Determining effective use of ER skills relies on adequate measurements. Typical methods of data collection in children present consistent shortcomings. This review addresses research findings considering the suitability of the late positive potential measured through electroencephalogram as a neural indicator of ER in children and youth. There is growing evidence, as reported in this review, that indicates that the late positive potential may be a reliable neural indicator of children's cognitive reappraisal abilities more specifically. Results generally suggest that the late positive potential amplitudes are sensitive to directed reappraisal in children. However, given the scant research, questions remain regarding developmental trends, methodology, interindividual variability, reappraisal of various stimuli, and how the late positive potential may relate to more traditional measures of ER. Directions for future research are provided, which are expected to address unanswered research questions and fill literature gaps. Taken together, the findings reviewed indicate that the late positive potential is generally sensitive to directed cognitive reappraisal in children and that there is promise of establishing this neural marker as an indicator of ER.

13.
Arts Health ; 12(1): 23-37, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31038428

RESUMO

Background: Starting in 2013, the Mental Health Youth Action Board, made up of 15 teens ages 15-18, was created to advise a large children's hospital on improvements in mental health care and produce social action projects to impact community perceptions of mental health.Methods: This participatory qualitative case study explored the experiences of 14 young people who participated in the Mental Health Youth Action Board between 2013 and 2016.Results: There were two higher order themes: process and outcomes. Process-related themes included how this was a unique leadership experience, the importance of the arts-based approach, and value of the intentionally constructed storytelling process. These processes led to youth growing as advocates for mental health.Conclusions: Arts-based approaches to social action that allow youth to share personal experiences of stigmatized topics can promote healing and support their growth as leaders.


Assuntos
Arte , Transtornos Mentais/psicologia , Ativismo Político , Estigma Social , Adolescente , Serviços de Saúde do Adolescente , Colorado , Feminino , Processos Grupais , Humanos , Masculino
14.
Am J Community Psychol ; 63(1-2): 208-226, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30843254

RESUMO

Over the last twenty years, research on the impact of engaging children and adolescents in the generation of new knowledge about their lives, schools, and communities, has grown tremendously. This systematic review summarizes the findings from empirical studies of youth inquiry approaches in the United States, with a focus on their environmental outcomes. Searches of four interdisciplinary databases retrieved a total of 3,724 relevant articles published between 1995 and 2015. Sixty-three distinct studies met the systematic review inclusion criteria, of which, 36 (57.1%) reported that the youth inquiry approach contributed to positive changes among adults, peers, organizations, and/or institutions. These environmental outcomes were qualitatively recorded, inductively categorized, and then organized into Bronfenbrenner's ecological framework. Youth inquiry approaches led to practitioner growth and changes in peer group norms at the micro-system level, program development or improvement and research benefits at the meso-system level, and school, city, and state level policy adoption at the exo-system level. Qualitative methods, especially case studies, were most commonly used to evaluate the impact of youth inquiry approaches on environmental outcomes. Studies of approaches that utilized advocacy to create change, targeted decision-makers as the audience for the youth's work and convened for a longer duration were more likely to report improved environmental outcomes. This systematic review suggests that youth inquiry approaches are a promising strategy for ecological systems change.


Assuntos
Participação da Comunidade , Pesquisa Participativa Baseada na Comunidade , Participação Social , Adolescente , Adulto , Coleta de Dados , Humanos , Pessoa de Meia-Idade , Projetos de Pesquisa , Instituições Acadêmicas , Meio Social , Estados Unidos , Adulto Jovem
15.
J Prim Prev ; 40(1): 35-49, 2019 02.
Artigo em Inglês | MEDLINE | ID: mdl-30659405

RESUMO

In the field of prevention science, some consider fidelity to manualized protocols to be a hallmark of successful implementation. A growing number of scholars agree that high-quality implementation should also include some adaptations to local context, particularly as prevention programs are scaled up, in order to strengthen their relevance and increase participant engagement. From this perspective, fidelity and adaptation can both be seen as necessary, albeit mutually exclusive, dimensions of implementation quality. In this article, we propose that the relationship between these two constructs may be more complex, particularly when adaptations are consistent with the key principles underlying the program model. Our argument draws on examples from the implementation of a manualized youth voice program (YVP) in two different organizations serving six distinct communities. Through a series of retreats, implementers identified examples of modifications made and grouped them into themes. Results suggest that some adaptations were actually indicators of fidelity to the key principles of YVPs: power-sharing, youth ownership, and engagement in social change. We therefore offer suggestions for re-conceptualizing the fidelity-adaptation debate, highlight implications for measurement and assessment, and illustrate that the de facto treatment of adaptation and fidelity as opposing constructs may limit the diffusion or scaling up of these types of youth programs.


Assuntos
Desenvolvimento do Adolescente , Comunicação , Pesquisa sobre Serviços de Saúde , Ciência da Implementação , Liderança , Serviços Preventivos de Saúde/organização & administração , Adolescente , Colorado , Feminino , Humanos , Masculino , Desenvolvimento de Programas , Avaliação de Programas e Projetos de Saúde , Mudança Social
16.
Health Educ Behav ; 45(6): 865-878, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-29749267

RESUMO

OBJECTIVES: To use a systematic review methodology to describe the state of the youth participatory action research (YPAR) literature and synthesize findings about the youth outcomes reported in these studies. METHODS: We screened and coded studies using a process consistent with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Of the 3,724 articles found in the database search, 67 reports of 63 distinct studies were included in the final sample. These reports were coded for reports of YPAR principles and project characteristics, study methods, and reported youth outcomes. RESULTS: The YPAR literature comprises predominantly qualitative studies, with only two randomized trials. The most common outcomes associated with participation in YPAR were those related to agency and leadership (75.0%), followed by academic or career (55.8%), social (36.5%), interpersonal (34.6%), and cognitive (23.1%) outcomes. CONCLUSIONS: This systematic review provides emerging evidence of the skills and competencies youth may develop through YPAR and offers methodological recommendations for future research that can provide greater evidence of causality.


Assuntos
Pesquisa Participativa Baseada na Comunidade , Liderança , Mudança Social , Adolescente , Humanos , Relações Interpessoais , Instituições Acadêmicas , Estados Unidos , Adulto Jovem
17.
J Homosex ; 65(9): 1207-1231, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29199908

RESUMO

Happy marriages provide protective health benefits, and social support is a key factor in this association. However, previous research indicates one of the greatest differences between same- and different-sex couples is less social support for same-sex couples. Our goal was to examine the extent to which formal markers of couple status (e.g., marriage) impact wellbeing among same-sex married partners. Using a mixed-methods approach, data were collected from 218 primarily White gay and lesbian individuals in the Midwest. Quantitative analysis revealed individuals in a prior formal union with a different-sex partner reported the lowest levels of sexuality specific social support and acceptance. Qualitative analysis revealed four primary impacts of marriage on support from family, friends, and co-workers: no change, increased support, decreased support, and a synthesis of mixed support. Three mechanisms prompting change in the family were identified and are presented.


Assuntos
Homossexualidade Feminina , Homossexualidade Masculina , Casamento , Adulto , Idoso , Feminino , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Parceiros Sexuais , Minorias Sexuais e de Gênero , Apoio Social , Adulto Jovem
18.
J Crit Care ; 30(6): 1331-7, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26365001

RESUMO

OBJECTIVE: To reduce transfer time of critically ill patients from the emergency department (ED) to the medical intensive care unit (MICU). DESIGN: A prospective, observational study assessing preimplementation and postimplementation of quality improvement interventions in a tertiary academic medical center. INTERVENTIONS: A team of frontline health care professional including ED, MICU, and supporting services using the clinical microsystems approach mapped out existing practice patterns, determined causes for delays, and used the Plan-Do-Study-Act to test changes. Measurements and Main Results The team identified multiple issues that contributed to delays. These included poor coordination between transport services, respiratory therapy, and nursing in transferring patients from the ED as well delays in identification and transfer of stable MICU patients. These interventions reduced transfer time from 4.2 (3.4-5.7) hours to 2.2 (1.4-3.1) hours (median [interquartile range]; P<.001). Hospital length of stay decreased from 9.9±9 to 8.3±7 days (P<.03). CONCLUSION: A team made up of frontline health care professionals using a structured quality improvement process and implementing multifaceted, multistage interventions, reduced transfer delays, and length of stay. Added benefits included engagement among members of the 2 microsystems and a more cohesive approach to patient care.


Assuntos
Serviço Hospitalar de Emergência/organização & administração , Unidades de Terapia Intensiva/organização & administração , Transferência de Pacientes/normas , Melhoria de Qualidade/estatística & dados numéricos , Centros Médicos Acadêmicos/organização & administração , Estado Terminal/terapia , Serviço Hospitalar de Emergência/estatística & dados numéricos , Feminino , Humanos , Unidades de Terapia Intensiva/estatística & dados numéricos , Tempo de Internação/estatística & dados numéricos , Masculino , Cidade de Nova Iorque , Transferência de Pacientes/estatística & dados numéricos , Padrões de Prática Médica/normas , Estudos Prospectivos
19.
J Immunol ; 195(3): 953-64, 2015 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-26116508

RESUMO

NF-κB-inducing kinase (NIK) is a primary regulator of the noncanonical NF-κB signaling pathway, which plays a vital role downstream of BAFF, CD40L, lymphotoxin, and other inflammatory mediators. Germline deletion or inactivation of NIK in mice results in the defective development of B cells and secondary lymphoid organs, but the role of NIK in adult animals has not been studied. To address this, we generated mice containing a conditional allele of NIK. Deletion of NIK in adult mice results in decreases in B cell populations in lymph nodes and spleen, similar to what is observed upon blockade of BAFF. Consistent with this, B cells from mice in which NIK is acutely deleted fail to respond to BAFF stimulation in vitro and in vivo. In addition, mice with induced NIK deletion exhibit a significant decrease in germinal center B cells and serum IgA, which is indicative of roles for NIK in additional pathways beyond BAFF signaling. Our conditional NIK-knockout mice may be broadly useful for assessing the postdevelopmental and cell-specific roles of NIK and the noncanonical NF-κB pathway in mice.


Assuntos
Fator Ativador de Células B/genética , Linfócitos B/imunologia , Ativação Linfocitária/genética , Subunidade p52 de NF-kappa B/biossíntese , Proteínas Serina-Treonina Quinases/genética , Animais , Linfócitos B/citologia , Diferenciação Celular/imunologia , Sobrevivência Celular/genética , Sobrevivência Celular/imunologia , Mutação em Linhagem Germinativa , Quinase I-kappa B/metabolismo , Imunoglobulina A/sangue , Linfonodos/citologia , Ativação Linfocitária/imunologia , Camundongos , Camundongos Knockout , Subunidade p52 de NF-kappa B/genética , Deleção de Sequência , Transdução de Sinais/genética , Transdução de Sinais/imunologia , Baço/citologia , Tamoxifeno/farmacologia , Quinase Induzida por NF-kappaB
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